Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
2007
The Role of Immune Reactions in Cancer Transformation
publication
Author Information
Author(s): Prehn Richmond T
Primary Institution: Department of Pathology, University of Washington
Hypothesis
Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
Conclusion
The study suggests that immune reactions may facilitate tumor growth and transformation, particularly during the transition from benign to malignant states.
Supporting Evidence
- Evidence suggests that immunity may have a major facilitating effect on tumor growth during malignant transformation.
- Most benign lesions rarely progress to malignancy, indicating a complex relationship between immunity and tumor development.
- Immunodepression has been shown to influence tumor incidence and progression in various studies.
Takeaway
The immune system can sometimes help tumors grow instead of fighting them, especially when tumors change from harmless to harmful.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website