EGFR Immunostaining and Prognosis in Renal Cell Carcinoma
Author Information
Author(s): Kallio J P, Hirvikoski P, Helin H, Kellokumpu-Lehtinen P, Luukkaala T, Tammela T L J, Martikainen P M
Primary Institution: Tampere University Hospital
Hypothesis
The location of EGFR immunostaining is associated with prognosis in renal cell carcinoma.
Conclusion
Prominent membranous EGFR immunostaining is associated with good prognosis in renal cell carcinoma.
Supporting Evidence
- 73% of tumors showed positive EGFR immunostaining.
- Membranous staining was associated with a hazard ratio of 8.0 for good prognosis.
- Predominantly cytoplasmic staining was linked to poor prognosis.
Takeaway
This study found that where the EGFR protein is located in kidney cancer cells can help predict how well a patient will do.
Methodology
The study analyzed EGFR immunostaining in tissue samples from 134 patients who underwent radical nephrectomy for RCC.
Limitations
The study was limited to a single institution and may not be generalizable to other populations.
Participant Demographics
The study included 134 patients, 83 men and 51 women, with a median age of 64 years.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI 2.0–33.2
Statistical Significance
p=0.004
Digital Object Identifier (DOI)
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