Refractory fungal infection: Three case reports highlighting good practice
2024

Refractory Fungal Infections: Three Case Reports

Sample size: 3 publication Evidence: low

Author Information

Author(s): Barnes Rosemary, Enoch David A., Ingram Wendy, Martin Jessica, Clay Jennifer, Tyler Netta, White P Lewis

Hypothesis

Refractory invasive fungal disease is a significant clinical problem influenced by antifungal resistance and impaired immune responses.

Conclusion

The case series highlights the challenges in managing refractory fungal infections and the importance of accurate diagnosis and antifungal stewardship.

Supporting Evidence

  • Refractory invasive fungal disease is associated with high morbidity and mortality.
  • Antifungal resistance can be innate or acquired, complicating treatment.
  • Accurate diagnosis and monitoring are crucial for effective management.

Takeaway

This study talks about three patients who had tough-to-treat fungal infections, showing how important it is to get the right tests and treatments.

Methodology

Case series detailing the identification and management of three patients with refractory fungal infections.

Limitations

The study is based on only three cases, which may limit the generalizability of the findings.

Participant Demographics

Three patients: one 21-year-old woman, one 43-year-old man, and one 45-year-old man, all with different underlying health conditions.

Digital Object Identifier (DOI)

10.1016/j.mmcr.2024.100688

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