Long-Term Visual Field Progression in X-Linked Retinitis Pigmentosa Patients
Author Information
Author(s): Steensberg Alvilda Hemmingsen, Al-Hamdani Sermed, Hansen Michael Stormly, Klefter Oliver Niels, Bertelsen Mette, Hamann Steffen
Primary Institution: Copenhagen University Hospital—Rigshospitalet
Conclusion
The study illustrates the characteristic pattern of retinal degeneration and visual field preservation in patients with X-linked retinitis pigmentosa over a long-term period.
Supporting Evidence
- The study included 84 XLRP patients with a mean follow-up time of 14.6 years.
- Data were collected from the Danish Retinitis Pigmentosa Registry, covering the years 1948 to 2014.
- The RPGR and RP2 variants are responsible for 74% and 15% of XLRP cases, respectively.
Takeaway
This study looked at how vision changes over time in people with a specific eye disease called X-linked retinitis pigmentosa, showing that some parts of their vision can stay okay even as other parts get worse.
Methodology
Longitudinal data from 84 genetically confirmed XLRP patients were collected from the Danish Retinitis Pigmentosa Registry, covering the years 1948 to 2014, using Goldmann kinetic perimetry.
Participant Demographics
Patients included 57 with RPGR variants and 27 with RP2 variants, with a mean follow-up time of 14.6 years.
Digital Object Identifier (DOI)
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