Plasma Anti-Oxidant Levels and Acute Appendicitis
Author Information
Author(s): Ozdogan Mehmet, Devay Ali Onder, Gurer Ahmet, Ersoy Eren, Devay Seda Duygulu, Kulacoglu Hakan, Gundogdu Haldun
Primary Institution: Ataturk Teaching and Research Hospital, Department of General Surgery, Ankara, Turkey
Hypothesis
The study investigates the relationship between total anti-oxidant status and the severity of acute appendicitis.
Conclusion
A decrease in plasma total anti-oxidant capacity might be a predictor of the progression of inflammation to perforation in acute appendicitis.
Supporting Evidence
- Plasma CRP was significantly higher in patients with perforated appendicitis.
- TAS levels were significantly lower in advanced appendicitis compared to other groups.
- Patients with acute phlegmonous appendicitis had higher TAS levels than those with advanced appendicitis.
Takeaway
If your body's ability to fight off damage from bad stuff goes down, it might mean your appendicitis is getting worse.
Methodology
Fifty-one adult patients with acute appendicitis were studied, measuring plasma levels of C-reactive protein, malondialdehyde, and total anti-oxidant status preoperatively.
Potential Biases
Potential bias in patient selection and measurement of oxidative stress markers.
Limitations
The study may not generalize to all patients with appendicitis as it only included those undergoing surgery.
Participant Demographics
51 adult patients (22 females, 29 males) with a median age of 31 years.
Statistical Information
P-Value
0.008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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