Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics
2025

The Role of Gut Bacteria in Chemotherapy-Induced Diarrhea

publication Evidence: moderate

Author Information

Author(s): Jiang Wanrou, Wu Yongjun, He Xiuyun, Jiang Ling, Zhang Wanyi, Zheng Wenjuan, Hu Min, Zhu Chaofu

Primary Institution: Hospital of Chengdu University of Traditional Chinese Medicine

Hypothesis

This paper investigates how intestinal microbiota influence chemotherapy-induced diarrhea (CID) through immune responses in the gut.

Conclusion

The study suggests that restoring gut microbiota balance can help prevent and manage chemotherapy-induced diarrhea.

Supporting Evidence

  • Chemotherapy can cause significant changes in gut bacteria, leading to diarrhea.
  • Restoring beneficial bacteria may help improve gut health and reduce diarrhea.
  • Current treatments for diarrhea do not address the underlying microbiota imbalance.

Takeaway

Chemotherapy can upset the good bacteria in our gut, leading to diarrhea. This study looks at how fixing that balance can help.

Methodology

The paper reviews existing studies on the relationship between intestinal microbiota and chemotherapy-induced diarrhea.

Limitations

The study highlights the need for more extensive research to confirm findings and explore mechanisms.

Digital Object Identifier (DOI)

10.7150/jca.99421

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