Caffeic Acid from Erigeron annuus Leaf Protects Neuronal Cells
Author Information
Author(s): Jeong Chang-Ho, Jeong Hee Rok, Choi Gwi Nam, Kim Dae-Ok, Lee Uk, Heo Ho Jin
Primary Institution: Kyung Hee University
Hypothesis
This study examines the antioxidant and neuroprotective effects of various fractions of the methanolic extract of Erigeron annuus leaf and identifies active compounds of the extract.
Conclusion
Erigeron annuus leaf extracts containing caffeic acid as an active compound have antioxidative and neuroprotective effects on neuronal cells.
Supporting Evidence
- The butanol fraction had the highest antioxidant activity among all solvent fractions.
- Caffeic acid showed dose-dependent in vitro antioxidant activity.
- Caffeic acid protected neuronal cells against oxidative stress induced by hydrogen peroxide.
Takeaway
Caffeic acid from a plant called Erigeron annuus helps protect brain cells from damage caused by harmful substances.
Methodology
The study used various assays to test the antioxidant activities and neuroprotective effects of the methanolic extract and its fractions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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