Evaluating Heart Function in Pulmonary Hypertension
Author Information
Author(s): Sanz Javier, García-Alvarez Ana, Fernandez-Friera Leticia, Nair Ajith, Mirelis Jesus G, Sawit Simonette, Pinney Sean, Fuster Valentin
Primary Institution: Mount Sinai School of Medicine
Hypothesis
Can right ventriculo-arterial coupling be quantified in pulmonary hypertension using both standard catheterization and cardiac magnetic resonance?
Conclusion
Right ventriculo-arterial coupling can be assessed using both invasive and noninvasive methods, revealing that arterial load increases with disease severity while contractility does not.
Supporting Evidence
- Ea increased linearly with advancing severity of pulmonary hypertension.
- Emax initially increased but tended to decrease with more severe disease.
- The ratio Ea/Emax indicated uncoupling with more severe pulmonary hypertension.
- Emax was associated with right atrial pressure after adjustments.
- CMR approximated Ea/Emax noninvasively with high correlation to invasive measurements.
Takeaway
This study looks at how well the heart and blood vessels work together in people with high blood pressure in the lungs, showing that one part gets worse while the other doesn't keep up.
Methodology
The study involved 139 patients undergoing both cardiac magnetic resonance and right heart catheterization to evaluate pulmonary hypertension.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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