Non-protein coding RNA biomarkers and differential expression in cancers: a review
2008
Non-protein coding RNA biomarkers in cancer
publication
Evidence: moderate
Author Information
Author(s): Mallardo Massimo, Poltronieri Palmiro, D'Urso Oscar Fernando
Primary Institution: University of Napoli Federico II
Hypothesis
The review discusses the differential expression of non-protein coding RNAs (npcRNAs) in various cancers.
Conclusion
The study highlights the complexity of the RNA world and the role of functional RNAs in cancer cell growth control.
Supporting Evidence
- Various species of npcRNAs have been found differentially expressed in different types of cancer.
- Long RNAs can produce small RNA species, which are implicated in cancer.
- Many introns give rise to new RNA species that regulate essential proteins.
Takeaway
This study talks about tiny pieces of RNA that don't make proteins but help control how cells grow, especially in cancer.
Methodology
The review summarizes published data and new results on the expression of a subset of npcRNAs in cancer.
Digital Object Identifier (DOI)
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