Ontologies for the description of mouse phenotypes
2004
Describing Mouse Phenotypes with Ontologies
Sample size: 600000
publication
Evidence: moderate
Author Information
Author(s): G. V. Gkoutos, E. C. J. Green, A.-M. Mallon, A. Blake, S. Greenaway, J. M. Hancock, D. Davidson
Primary Institution: MRC Mammalian Genetics Unit, Harwell, UK
Hypothesis
Can ontologies be effectively used to describe mouse phenotypes?
Conclusion
The proposed schema allows for a flexible and detailed description of phenotypes across different organisms.
Supporting Evidence
- Ontologies help in the efficient storage and retrieval of biological data.
- The schema allows for the systematic description of phenotypes.
- 600,000 mutant mice phenotypes were annotated using the SHIRPA protocol.
- The approach enables interoperability between different species communities.
- Chameleon tools were developed for easy access and updates to the schema.
Takeaway
This study shows how we can use special systems called ontologies to better understand and describe the traits of mice.
Methodology
The study involved evaluating a schema for describing phenotypes by annotating data on 600,000 mutant mice using the SHIRPA protocol.
Limitations
The schema may not cover all possible information about a domain.
Participant Demographics
Mouse mutants used in the study.
Digital Object Identifier (DOI)
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