Biomarkers for COVID-19 Diagnosis and Prognosis
Author Information
Author(s): Ali Marwa A., Shaker Olfat G., Ezzat Eman M., Ali El Shaimaa Gomaa, Aboelor Mahmoud I., Ahmed Mona I., Hassan Essam A., Ali Doaa Y., Ahmed Heba Mostafa, Khalefa Abeer A., Hussein Rasha A., Elkhateeb Ahmed Fathy, Mohamed Esam Ali
Primary Institution: Fayoum University, Fayoum, Egypt
Hypothesis
Can the expression levels of NEAT-1, miR-374b-5p, and IL6 in the serum of COVID-19 patients correlate with clinical findings and disease severity?
Conclusion
The study found decreased levels of NEAT-1 and miR-374b-5p, and increased levels of IL6 in COVID-19 patients, indicating their potential as biomarkers.
Supporting Evidence
- NEAT-1 and miR-374b-5p levels were significantly lower in COVID-19 patients compared to controls.
- IL-6 levels were significantly higher in COVID-19 patients compared to controls.
- There was a negative correlation between NEAT-1 and IL-6 levels in COVID-19 patients.
- ROC analysis showed high sensitivity and specificity for NEAT-1 and IL-6 in diagnosing COVID-19.
Takeaway
This study looked at blood markers in COVID-19 patients to see if they can help doctors understand how sick someone is and how to treat them better.
Methodology
The study used quantitative real-time PCR and ELISA to measure serum levels of NEAT-1, miR-374b-5p, and IL6 in COVID-19 patients and controls.
Potential Biases
Potential biases may arise from the selection of participants and the exclusion of certain groups.
Limitations
The study had a relatively small sample size and was conducted in a single geographical area.
Participant Demographics
The study included 48 COVID-19 patients and 40 healthy controls, with no significant differences in age and sex.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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