Thiazolidinedione Induced Thyroid Associated Orbitopathy
Author Information
Author(s): Lee Seongmu, Tsirbas Angelo, Goldberg Robert A, McCann John D
Primary Institution: Jules Stein Eye Institute, David Geffen School of Medicine at UCLA
Hypothesis
Can thiazolidinediones exacerbate thyroid associated orbitopathy in diabetic patients with a history of autoimmune thyroid disorders?
Conclusion
Thiazolidinediones may exacerbate thyroid associated orbitopathy, and this should be considered when treating diabetic patients with autoimmune thyroid disorders.
Supporting Evidence
- The patient had stabilized thyroid associated orbitopathy for 2.5 years before starting TZD.
- After stopping TZD, the patient's condition stabilized and vision normalized.
- The study suggests a link between TZD use and exacerbation of thyroid associated orbitopathy.
Takeaway
A woman with thyroid issues got worse after starting a diabetes medication called thiazolidinedione, but her condition improved after stopping the medication.
Methodology
Case report of a female patient with Graves' disease and thyroid associated orbitopathy.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
56-year-old female smoker with a history of Graves' disease.
Digital Object Identifier (DOI)
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