Syzygium jambolanum treatment improves survival in lethal sepsis in mice
Author Information
Author(s): Maciel Márcia CG, Farias Jardel C, Maluf Michele J, Gomes Eliane A, Pereira Paulo VS, Aragão-Filho Walmir C, Frazão Josias B, Costa Graciomar C, Sousa Sanara M, Silva Lucilene A, Amaral Flávia MM, Russo Momtchilo, Guerra Rosane NM, Nascimento Flávia RF
Primary Institution: Federal University of Maranhão, São Luís, MA, Brazil
Hypothesis
Does prophylactic treatment with Syzygium jambolanum improve survival in mice with lethal sepsis induced by cecal ligation and puncture?
Conclusion
The treatment with Syzygium jambolanum has a potent prophylactic anti-septic effect associated with the recruitment of activated neutrophils to the infectious site and a reduced systemic inflammatory response.
Supporting Evidence
- The prophylactic treatment increased mice survival compared to the control group.
- Neutrophil migration to the infection site was enhanced in treated mice.
- The treatment decreased serum TNF and nitrite levels.
Takeaway
This study found that a plant called Syzygium jambolanum can help mice survive a serious infection by helping their immune system fight better.
Methodology
C57Bl/6 mice were treated with a hydroalcoholic extract of Syzygium jambolanum before inducing sepsis through cecal ligation and puncture.
Limitations
The study did not demonstrate a direct microbicidal effect of the treatment.
Participant Demographics
Male C57Bl/6 mice, 8-12 weeks old, weighing 20-25 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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