2-Chloro-N-(4-hydroxyphenyl)acetamide
Author Information
Author(s): El Moutaouakil Ala Allah Abderrazzak, Kariuki Benson M., Ameziane El Hassani Issam, Alsubari Abdulsalam, Guerrab Walid, Said Musa A., Ramli Youssef
Primary Institution: Laboratory of Medicinal Chemistry Drug Sciences Research Center Faculty of Medicine and Pharmacy Mohammed V University in Rabat Morocco
Conclusion
The compound exhibits a significant distortion from planarity with specific intra- and intermolecular interactions contributing to its crystal structure.
Supporting Evidence
- The compound has a twist angle of 23.5° between its hydroxybenzene and acetamide groups.
- Intramolecular C—H⋯O and N—H⋯Cl contacts support the conformation of the molecule.
- Hydrogen-bonding interactions in the crystal form linear chains of molecules.
Takeaway
The study describes a chemical compound that is not flat and has special connections between its parts, which help it form a solid structure.
Methodology
The compound was synthesized from 4-aminophenol and chloroacetyl chloride in acetic acid, followed by crystallization.
Digital Object Identifier (DOI)
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