Identifying a Chemoattractant Peptide in Milk for B Lymphoblasts
Author Information
Author(s): de Jesus Rodriguez Berardo, Chevaleyre Claire, Henry Gwénaële, Mollé Daniel, Virlogeux-Payant Isabelle, Berri Mustapha, Boulay François, Léonil Joëlle, Meurens François, Salmon Henri
Primary Institution: Institut National de la Recherche Agronomique (INRA)
Hypothesis
Whey from milk contains chemoattractants that recruit plasma cells to the mammary gland.
Conclusion
The study suggests that the SAA23–45 fragment plays a role in recruiting B-cells to the mammary gland, benefiting neonates.
Supporting Evidence
- The 2.7 kDa peptide attracted B-cell lymphoblasts at lower concentrations.
- More SAA transcripts were observed during lactation than gestation.
- Milk contains factors that increase lymphocyte migration.
Takeaway
The researchers found a special protein in milk that helps attract immune cells to protect baby animals.
Methodology
The study involved analyzing milk fractions for their ability to attract lymphocytes and identifying active peptides through chromatography and mass spectrometry.
Limitations
The study does not definitively identify the specific SAA subtype responsible for the observed effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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