Genetic Susceptibility to Moles: A Twin Study
Author Information
Author(s): D.F. Easton, G.M. Cox, A.M. Macdonald, B.A.J. Ponder
Primary Institution: Institute of Cancer Research
Hypothesis
Is there an inherited basis for the number of benign melanocytic naevi?
Conclusion
The study suggests a strong inherited basis for total naevus count and hence melanoma risk.
Supporting Evidence
- A strong correlation in total numbers of naevi was observed between MZ twins (intraclass correlation 0.83).
- There was no significant correlation between DZ twins (correlation -0.24).
- The results suggest that total naevus count has a strong inherited basis.
Takeaway
This study looked at twins to see if having more moles is something you inherit from your family. It found that identical twins tend to have similar numbers of moles, suggesting genetics play a big role.
Methodology
The study examined 23 monozygotic and 22 dizygotic twin pairs to assess the number of naevi.
Potential Biases
The examination was conducted by one nurse who was aware of the zygosity of the twins, which could introduce bias.
Limitations
The study was based on a volunteer register, and only 39% of contacted twins agreed to participate.
Participant Demographics
Twins aged 20-59, with a mix of male and female pairs, and non-whites were excluded.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
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