Siglec-15 Expression and Bladder Cancer Prognosis
Author Information
Author(s): Chu Chengbiao, Fu Yao, Yang Jun, Fan Xiangshan, Shi Jiong
Primary Institution: Nanjing Drum Tower Hospital, Nanjing, China
Hypothesis
Is there a relationship between Siglec-15 expression and the prognosis of bladder cancer?
Conclusion
High stromal Siglec-15 expression is associated with lower T stage and better prognosis in bladder cancer patients.
Supporting Evidence
- 84.1% of bladder cancer samples expressed Siglec-15 in tumor cells.
- Low stromal Siglec-15 expression was associated with advanced tumor stage.
- Stromal Siglec-15 expression was linked to better overall survival.
Takeaway
This study found that a protein called Siglec-15 is found in bladder cancer and having more of it in the surrounding tissue can mean a better chance of recovery.
Methodology
Immunohistochemical staining was used to assess Siglec-15 and PD-L1 expression in bladder cancer samples.
Potential Biases
Potential biases due to the retrospective nature of the study.
Limitations
The study is retrospective with a limited sample size and lacks biological experiments to clarify the role of Siglec-15.
Participant Demographics
Patients aged 43-92 years, with a mix of male and female participants.
Statistical Information
P-Value
0.010
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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