Insulin's Role in Wound Healing
Author Information
Author(s): Liu Yan, Petreaca Melissa, Yao Min, Martins-Green Manuela
Primary Institution: Burn Department, Ruijin hospital, Shanghai JiaoTong University Medical School, Shanghai, PR China; Department of Cell Biology and Neuroscience, University of California, Riverside, CA, USA
Hypothesis
Does insulin enhance keratinocyte function during wound healing?
Conclusion
Insulin accelerates wound healing by stimulating keratinocyte migration and differentiation.
Supporting Evidence
- Insulin significantly decreased wound area by day 3 after injury.
- Keratinocyte migration was significantly increased in insulin-treated wounds.
- Insulin treatment resulted in a better-defined epidermis with more epidermal reticular ridges.
Takeaway
Insulin helps heal wounds faster by making skin cells move and grow better.
Methodology
Insulin was applied to skin excision wounds in mice, and healing was monitored over time.
Limitations
The study primarily used mouse models, which may not fully replicate human wound healing.
Participant Demographics
C57BL/6J mice were used in the study.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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