Cheiradone: A Natural Antagonist of VEGF in Angiogenesis
Author Information
Author(s): Hussain Sajjad, Slevin Mark, Mesaik Mohammad A, Choudhary Mohammad I, Elosta Abdul H, Matou Sabine, Ahmed Nessar, West David, Gaffney John
Primary Institution: Manchester Metropolitan University
Hypothesis
Does cheiradone inhibit VEGF-induced angiogenesis?
Conclusion
Cheiradone inhibits VEGF-induced angiogenesis by binding to VEGF receptors -1 and -2.
Supporting Evidence
- Cheiradone inhibited VEGF-induced cell proliferation with IC50 values of 7.4 and 7.8 μM.
- Cheiradone significantly inhibited VEGF-induced migration of endothelial cells.
- In vivo, cheiradone completely abolished VEGF-induced blood vessel formation in the CAM assay.
Takeaway
Cheiradone is a natural substance that stops the growth of new blood vessels by blocking a specific signal that tells cells to grow.
Methodology
The study used in vitro and in vivo models to test the effects of cheiradone on VEGF-induced angiogenesis.
Limitations
The study did not explore the long-term effects of cheiradone or its interactions with other growth factors.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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