Increasing chromosome 1 copy number parallels histological progression in breast carcinogenesis
2000
Chromosome 1 Changes in Breast Cancer Progression
Sample size: 7
publication
Evidence: moderate
Author Information
Author(s): Cummings M C, Aubele M, Mattis A, Purdie D, Hutzler P, Höfler H, Werner M
Primary Institution: University of Queensland Medical School
Hypothesis
Increasing chromosome 1 copy number parallels histological progression in breast carcinogenesis.
Conclusion
The study found that benign breast lesions show increasing chromosome 1 copy numbers that correlate with the progression to more severe forms of breast cancer.
Supporting Evidence
- The mean signal number for normal cells was 1.14, while that for hyperplasia was 1.56 and ADH was 1.5.
- Values for DCIS were 1.95 and invasive duct carcinoma were 1.79.
- Six of the seven cases showed a significant trend towards an increasing proportion of cells with greater than 2 signals per nucleus.
Takeaway
This study shows that changes in chromosome 1 can help us understand how breast diseases can turn into cancer.
Methodology
Fluorescence in situ hybridization was used to investigate chromosome 1 copy number in breast lesions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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