The Role of CD98hc in Early Mouse Development
Author Information
Author(s): Sato Yukiyasu, Heimeier Rachel A, Li Cuiling, Deng Chuxia, Shi Yun-Bo
Primary Institution: NICHD, NIH, Bethesda, Maryland, USA
Hypothesis
The extracellular domain of CD98hc is essential for early murine development.
Conclusion
CD98hc is crucial for early post-implantation development in mice, likely due to its role in integrin signaling and amino acid transport.
Supporting Evidence
- CD98hc-null mice show early post-implantation lethality.
- CD98hc interacts with integrin β1, which is important for cell adhesion.
- Mutant CD98hc protein can still interact with integrin β1 but fails to support amino acid transport.
Takeaway
CD98hc helps mice grow properly before they are born, and without it, they can't develop well.
Methodology
Mice were generated from embryonic stem cells with a mutant CD98hc allele, and various analyses were performed to assess the role of CD98hc in development.
Limitations
The study primarily focuses on the role of CD98hc in early development and does not explore later stages or other potential functions.
Digital Object Identifier (DOI)
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