Comparing Insulin Glulisine and Insulin Aspart in Obese Patients with Type 2 Diabetes
Author Information
Author(s): Bolli G B, Luzio S, Marzotti S, Porcellati F, Sert-Langeron C, Charbonnel B, Zair Y, Owens D R
Primary Institution: University of Perugia
Hypothesis
This study aims to compare the pharmacokinetic and pharmacodynamic properties of insulin glulisine and insulin aspart in obese subjects with type 2 diabetes.
Conclusion
Insulin glulisine resulted in lower glucose levels during the first hour after a meal compared to insulin aspart, but overall glucose profiles were similar.
Supporting Evidence
- Glulisine resulted in significantly lower glucose levels during the first hour after a meal compared to aspart.
- Peak insulin concentration was significantly higher for glulisine than for aspart.
- Hypoglycaemic events occurred in 13 subjects treated with glulisine and 16 with aspart.
Takeaway
This study found that a new type of insulin called glulisine works faster to lower blood sugar right after eating compared to another type called aspart.
Methodology
A randomized, double-blind, two-way crossover trial with 30 obese subjects receiving either insulin glulisine or aspart before a standardized meal.
Potential Biases
Potential bias due to the small sample size and specific inclusion criteria.
Limitations
The study had a small sample size and results may not be generalizable due to the controlled meal size and content.
Participant Demographics
30 obese subjects (mean age 60.7 years, 9 females and 21 males) with type 2 diabetes.
Statistical Information
P-Value
0.0455
Confidence Interval
90% CI: 90–99
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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