Role of SHAP-HA Complex in Endometrial Cancer
Author Information
Author(s): Yabushita Hiromitsu, Iwasaki Keita, Kanyama Kouhei, Obayashi Yukihiko, Zhuo Lisheng, Itano Naoki, Kimata Koji, Wakatsuki Akihiko
Primary Institution: Aichi Medical University
Hypothesis
The study investigates the relationship between serum-derived hyaluronan-associated protein (SHAP)-hyaluronan complex and endometrial cancer outcomes.
Conclusion
The SHAP-HA complex is a useful marker to predict disease recurrence in endometrial cancer patients.
Supporting Evidence
- Serum levels of SHAP-HA complex were higher in endometrial cancer patients compared to healthy controls.
- Patients with elevated SHAP-HA complex had shorter disease-free survival.
- SHAP-HA complex levels correlated with MMP-9 and TIMP-1 levels.
Takeaway
This study found that a protein complex in the blood can help doctors predict if endometrial cancer will come back after treatment.
Methodology
The study analyzed serum and tissue samples from 50 patients with endometrioid adenocarcinoma and measured levels of SHAP-HA complex, HA, MMP-9, and TIMP-1.
Limitations
The study only included patients diagnosed at stage I and may not be generalizable to all endometrial cancer stages.
Participant Demographics
Mean age of endometrial cancer patients was 57.24 years, and healthy controls were 54.52 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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