Study on Sacubitril/Valsartan Safety in Older Adults
Author Information
Author(s): Kuai Zheng, Hu Yu
Primary Institution: Zhongshan Hospital, Fudan University, Shanghai, China
Hypothesis
There is a lack of systematic studies on sacubitril/valsartan-related adverse events in older people.
Conclusion
The study identified potential new adverse event signals associated with sacubitril/valsartan in older adults.
Supporting Evidence
- 94,210 sacubitril/valsartan-associated cases were retrieved.
- 86 preferred terms with significant disproportionality were identified in older adults.
- Adverse events like angioedema and hypotension were reported at rates similar to clinical trials.
- Unexpected safety signals were detected only in older adults.
Takeaway
This study looked at older people taking a heart medication and found some unexpected side effects that doctors should watch for.
Methodology
Disproportionality analyses were used to quantify adverse event signals.
Potential Biases
There may be reporting bias in the adverse event data collected.
Limitations
The study may not cover all potential adverse events due to the nature of reporting databases.
Participant Demographics
Older adults aged 65 and above.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website