Comparing r-FSH and HP-uFSH for Ovulation Induction
Author Information
Author(s): Revelli Alberto, Poso Francesca, Gennarelli Gianluca, Moffa Federica, Grassi Giuseppina, Massobrio Marco
Primary Institution: University of Torino, S. Anna Hospital, Torino, Italy
Hypothesis
Is recombinant FSH (r-FSH) more cost-effective than highly-purified urinary FSH (HP-uFSH) for ovulation induction?
Conclusion
The study found that r-FSH resulted in a 9.4% reduction in overall therapy cost per delivered baby compared to HP-uFSH.
Supporting Evidence
- The total FSH dose needed to achieve ovulation was significantly lower with r-FSH.
- Both treatments resulted in similar delivery rates, but r-FSH had a slight edge.
- Cost-minimization analysis showed r-FSH to be more economical per delivered baby.
Takeaway
This study looked at two types of medicines used to help women get pregnant and found that one type, r-FSH, is cheaper overall even though it costs more per dose.
Methodology
The study randomized 260 infertile women to receive either r-FSH or HP-uFSH for ovulation induction and compared the costs and outcomes.
Limitations
The study only included first treatment cycles and did not account for all types of infertility.
Participant Demographics
Women aged 28-38, with unexplained infertility or CC-resistant PCOS.
Statistical Information
P-Value
0.0003
Confidence Interval
95%CI: 4.5–15.2
Statistical Significance
p<0.0003
Digital Object Identifier (DOI)
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