Chlorhexidine vs. Sterile Vaginal Wash During Labor to Prevent Neonatal Infection
Author Information
Author(s): Nancy L. Eriksen, Keri M. Sweeten, Jorge D. Blanco
Primary Institution: University of Texas Health Science Center
Hypothesis
Can a dilute solution of chlorhexidine used as a one-time vaginal wash during labor reduce the use of postnatal antibiotics and neonatal infection?
Conclusion
A one-time chlorhexidine vaginal wash does not decrease the use of antibiotics or incidence of neonatal infection.
Supporting Evidence
- 15 neonates (3.2%) in the chlorhexidine group received antibiotics compared to 9 (1.9%) in the control group.
- There was one case of pneumonia in the control group and no cases of sepsis in either group.
- The length of ruptured membranes was not significantly different between the two groups.
Takeaway
The study tested if washing with chlorhexidine during labor helps babies avoid infections, but it didn't make a difference.
Methodology
Term pregnant women in labor were randomized to receive either chlorhexidine or sterile water, and outcomes were measured.
Potential Biases
The study was not blinded due to the visible difference in the solutions used.
Limitations
The study may not have had enough participants to detect a small difference in antibiotic use.
Participant Demographics
Women admitted to labor and delivery at 36 weeks or greater gestational age.
Statistical Information
P-Value
0.32
Confidence Interval
0.72-3.72
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website