The effect of lyso-PAF on ciliary activity of human paranasal sinus mucosa in vitro
1994
Effect of Lyso-PAF on Ciliary Activity in Human Sinus Mucosa
Sample size: 5
publication
Evidence: moderate
Author Information
Author(s): T. Ganbo, K. Hisamatsu, H. Inoue, T. Nakajima, Y. Murakami
Primary Institution: Yamanshi Medical University
Hypothesis
Lyso-PAF inhibits ciliary activity in human paranasal sinus mucosa.
Conclusion
Lyso-PAF significantly inhibits ciliary activity, but this effect is temporary and reversible.
Supporting Evidence
- Ciliary activity was significantly inhibited by 10-8 M lyso-PAF.
- The effect of lyso-PAF was completely blocked by CV-6209.
- PAF concentration in the incubation medium increased after exposure to lyso-PAF.
Takeaway
When a substance called lyso-PAF is added to cells from the nose, it makes the tiny hairs on those cells stop moving, but they can start moving again later.
Methodology
Normal mucosa was obtained from patients and incubated in tissue culture to observe ciliary activity under various conditions.
Limitations
The variability in mucosal volume and enzyme activity may affect the results.
Participant Demographics
Patients who suffered from facial trauma.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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