Body Mass Index and Diabetes in Asia
Author Information
Author(s): Boffetta Paolo, McLerran Dale, Chen Yu, Inoue Manami, Sinha Rashmi, He Jiang, Gupta Prakash Chandra, Tsugane Shoichiro, Irie Fujiko, Tamakoshi Akiko, Gao Yu-Tang, Shu Xiao-Ou, Wang Renwei, Tsuji Ichiro, Kuriyama Shinichi, Matsuo Keitaro, Satoh Hiroshi, Chen Chien-Jen, Yuan Jian-Min, Yoo Keun-Young, Ahsan Habibul, Pan Wen-Harn, Gu Dongfeng, Pednekar Mangesh Suryakant, Sasazuki Shizuka, Sairenchi Toshimi, Yang Gong, Xiang Yong-Bing, Nagai Masato, Tanaka Hideo, Nishino Yoshikazu, You San-Lin, Koh Woon-Puay, Park Sue K., Shen Chen-Yang, Thornquist Mark, Kang Daehee, Rolland Betsy, Feng Ziding, Zheng Wei, Potter John D.
Primary Institution: Fred Hutchinson Cancer Research Center
Hypothesis
What is the association between body mass index (BMI) and diabetes prevalence in Asian populations?
Conclusion
The study found a strong relationship between increased body mass and prevalence of diabetes in Asian populations.
Supporting Evidence
- The prevalence of diabetes was 4.3% in the overall population.
- The odds ratio for diabetes increased with higher BMI categories.
- Individuals below age 50 showed a stronger association between BMI and diabetes prevalence.
- Diabetes prevalence was lower in India and Bangladesh compared to other countries.
- Self-reported diabetes status was validated by additional indicators in some cohorts.
- Adjustment for confounding factors did not significantly alter the results.
- Repeated BMI measurements indicated a decrease in BMI over time among individuals with diabetes.
Takeaway
This study looked at a lot of people in Asia to see how being overweight affects diabetes. They found that being heavier makes it more likely to have diabetes.
Methodology
A pooled cross-sectional analysis using logistic regression models to evaluate the association between BMI and self-reported diabetes status.
Potential Biases
Potential misclassification of diabetes status due to self-reporting.
Limitations
Self-reported diabetes status may lead to misclassification, and the cross-sectional design prevents studying the incidence of diabetes.
Participant Demographics
Participants were from 18 cohorts across Bangladesh, China, India, Japan, Korea, Singapore, and Taiwan, with a mean age of 54.5 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 0.31, 0.76 for BMI <15.0 kg/m2; 95% CI 1.86, 2.67 for BMI >34.9 kg/m2
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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