Chronic Kidney Disease Prevalence in HIV/AIDS Patients in Burundi
Author Information
Author(s): Cailhol Johann, Nkurunziza Béatrice, Izzedine Hassan, Nindagiye Emmanuel, Munyana Laurence, Baramperanye Evelyne, Nzorijana Janvière, Sakubu Désiré, Niyongabo Théodore, Bouchaud Olivier
Primary Institution: Infectious and tropical diseases department, Avicenne Hospital-APHP and Paris 13 University
Hypothesis
What is the prevalence and nature of chronic kidney disease among people living with HIV/AIDS in Burundi?
Conclusion
The study suggests a potentially high prevalence of chronic kidney disease among people living with HIV/AIDS in Burundi.
Supporting Evidence
- CKD prevalence was found to be 45.7% using the MDRD method.
- 30.2% of CKD patients were classified as stage 1 according to NKF classification.
- Significant associations were found between LEU and factors like NSAID use and previous history of tuberculosis.
Takeaway
Almost half of the people with HIV in Burundi have kidney problems, so doctors need to check their kidneys regularly.
Methodology
A multicenter cross-sectional study was conducted with assessments at baseline and 3 months later, using GFR estimation methods and logistic regression for risk factors.
Potential Biases
Potential underdiagnosis of tuberculosis and urinary infections could bias results.
Limitations
Ultrasound and renal biopsy were not performed, which limited precise diagnosis; underdiagnosis of infections may have led to overestimation of CKD prevalence.
Participant Demographics
Median age was 40 years, 70.3% were female, and 71.7% were on highly active antiretroviral therapy.
Statistical Information
P-Value
p<0.01
Confidence Interval
[39.7-51.7]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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