PPARγ agonists inhibit growth and expansion of CD133+ brain tumour stem cells
2008
PPARγ Agonists and Brain Tumor Stem Cells
publication
Evidence: moderate
Author Information
Author(s): Chearwae W, Bright J J
Primary Institution: Methodist Research Institute at Clarian Health, Indianapolis, IN, USA
Hypothesis
PPARγ agonists inhibit the growth and expansion of CD133+ brain tumor stem cells.
Conclusion
PPARγ agonists effectively inhibit the proliferation and expansion of brain tumor stem cells, suggesting their potential use in brain tumor treatment.
Supporting Evidence
- PPARγ agonists induced growth arrest and apoptosis in glioblastoma cells.
- Treatment with PPARγ agonists resulted in a significant decrease in the number of CD133+ cells in gliospheres.
- PPARγ agonists inhibited the proliferation of BTSCs in a dose-dependent manner.
- PPARγ agonists induced cell cycle arrest and apoptosis in gliosphere cells.
Takeaway
This study found that certain drugs can stop brain tumor stem cells from growing, which could help in treating brain tumors.
Methodology
The study involved culturing glioblastoma cells to form gliospheres and treating them with PPARγ agonists to assess their effects on growth and apoptosis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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