FGF9 and Eosinophilic Oesophagitis
Author Information
Author(s): Mulder D J, Pacheco I, Hurlbut D J, Mak N, Furuta G T, MacLeod R J, Justinich C J
Primary Institution: Queen’s University
Hypothesis
MBP released from eosinophils acts on oesophageal epithelial cells to cause changes in oesophagitis.
Conclusion
Eosinophil-released MBP increases FGF9 in oesophageal epithelial cells, leading to proliferation, and increased FGF9 is found in biopsies of EoE patients.
Supporting Evidence
- FGF9 was secreted by HET-1A cells treated with polyarginine and MBP-peptide.
- FGF9 was increased in biopsies from patients with eosinophilic oesophagitis.
- HET-1A cells proliferated following rhFGF9 treatment.
- Patients with EoE had abnormal endoscopic features and increased eosinophils.
Takeaway
When eosinophils release a protein called MBP, it makes another protein called FGF9 that helps cells in the esophagus grow too much, which can cause problems.
Methodology
Human oesophageal epithelial cells were treated with MBP-peptide and polyarginine to measure FGF9 production and cell proliferation.
Limitations
The study is limited to a small sample size and specific patient demographics.
Participant Demographics
21 pediatric patients, average age 10.4 years, with 71.4% male in the EoE group.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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