NF-κB Activation in Prostate Cancer and Its Link to Relapse
Author Information
Author(s): Domingo-Domenech J, Mellado B, Ferrer B, Truan D, Codony-Servat J, Sauleda S, Alcover J, Campo E, Gascon P, Rovira A, Ross J S, Fernández P L, Albanell J
Primary Institution: Hospital Clinic & Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Hypothesis
Does nuclear localization of NF-κB predict biochemical relapse in prostate cancer?
Conclusion
Nuclear localization of NF-κB is an independent prognostic factor for biochemical relapse in prostate cancer.
Supporting Evidence
- Nuclear localization of NF-κB was associated with biochemical relapse.
- Patients with positive nuclear NF-κB expression had a median time to biochemical relapse of 44 months.
- 5-year biochemical relapse-free survival was 34% in patients with positive nuclear NF-κB staining.
Takeaway
This study found that when NF-κB is active in the nucleus of prostate cancer cells, it can help predict if the cancer will come back after treatment.
Methodology
Immunohistochemistry was used to assess NF-κB expression in prostate tissue specimens from patients.
Limitations
The study does not establish the functional relevance of NF-κB activation in terms of transcriptional activity.
Participant Demographics
Patients with prostate adenocarcinoma, mean age 66 years.
Statistical Information
P-Value
0.0009
Statistical Significance
p=0.0009
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website