Comparative Evaluation of Norfloxacin Formulations for Burn Wound Healing
Author Information
Author(s): Malipeddi Venkata Ramana, Dua Kamal, Sara Udai Vir Singh, Malipeddi Himaja, Agrawal Abhinav
Primary Institution: NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka
Hypothesis
The study aims to evaluate the effectiveness of various semisolid formulations of norfloxacin compared to silver sulfadiazine cream for burn wound healing.
Conclusion
Norfloxacin semisolid formulations showed burn wound healing properties comparable to silver sulfadiazine cream.
Supporting Evidence
- Norfloxacin formulations showed better in vitro release profiles compared to creams.
- Statistically significant wound healing activity was observed in all formulations tested.
- Carbopol gel base formulations had the highest percent wound healing.
Takeaway
This study tested different creams to help heal burn wounds, and found that a new cream with norfloxacin works just as well as a common one.
Methodology
Various semisolid formulations of norfloxacin were prepared and evaluated for antimicrobial activity and burn wound healing properties in Wistar albino rats.
Participant Demographics
Healthy Wistar albino rats weighing between 150 and 180 g.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.001
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