Antihypertensive Effects of Eupalitin 3-O-β-D-galactopyranoside from Boerhavia diffusa
Author Information
Author(s): Uoorakkottil Ilyas, Koottangodan Rashid, Thajudheen Kamal Y., Alsheri Saad Ali, Ahmed Mohammed Muqtader
Primary Institution: Moulana College of Pharmacy, Perinthalmanna, India
Hypothesis
Does eupalitin 3-O-β-D-galactopyranoside exhibit antihypertensive activity in hypertensive rats?
Conclusion
Eupalitin 3-O-β-D-galactopyranoside significantly reduces blood pressure in hypertensive rats, indicating its potential as a natural treatment for hypertension.
Supporting Evidence
- Eupalitin 3-O-β-D-galactopyranoside significantly lowered both systolic and diastolic blood pressure in hypertensive rats.
- The compound showed a dose-dependent response in reducing blood pressure.
- Pharmacokinetic studies indicated moderate bioavailability of eupalitin 3-O-β-D-galactopyranoside.
Takeaway
A natural compound from a plant can help lower high blood pressure in rats, which might help people with hypertension too.
Methodology
The study involved isolating eupalitin 3-O-β-D-galactopyranoside from Boerhavia diffusa, inducing hypertension in rats, and measuring blood pressure changes after treatment with the compound.
Potential Biases
Potential biases in animal selection and treatment allocation were assessed using SYRCLE’s Risk of Bias tool.
Limitations
The study was limited to a specific animal model and did not explore the toxicity profiles of the compound.
Participant Demographics
Albino rats weighing 100-200 g were used in the study.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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