TBLR1 regulates the expression of nuclear hormone receptor co-repressors
2006
TBLR1 and Its Role in Gene Regulation
publication
Evidence: moderate
Author Information
Author(s): Zhang Xin-Min, Chang Qing, Zeng Lin, Gu Judy, Brown Stuart, Basch Ross S
Primary Institution: New York University School of Medicine
Hypothesis
TBLR1 regulates the expression of nuclear hormone receptor co-repressors.
Conclusion
TBLR1 is a multifunctional co-repressor of transcription that plays an important role in regulating differentiation.
Supporting Evidence
- TBLR1 interacts with proteins that regulate nuclear hormone receptor activity.
- Overexpression of TBLR1 leads to growth arrest in cells.
- TBLR1 stabilizes co-repressors by preventing their degradation.
Takeaway
TBLR1 is a protein that helps control how genes are turned on and off, which is important for how cells grow and develop.
Methodology
The study involved cloning the TBLR1 gene, analyzing its expression in various tissues, and examining its interactions with other proteins.
Digital Object Identifier (DOI)
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