Dried Plum and Fructooligosaccharides Help Bone Health in Rats
Author Information
Author(s): Catherine D. Johnson, Edralin A. Lucas, Shirin Hooshmand, Sara Campbell, Mohammed P. Akhter, Bahram H. Arjmandi
Primary Institution: Florida State University
Hypothesis
Can the combination of dried plum and fructooligosaccharides in a soy-based diet restore bone mass in ovariectomized rats?
Conclusion
The combination of dried plum and fructooligosaccharides with soy protein significantly improved bone mineral density in ovariectomized rats.
Supporting Evidence
- Soy protein combined with dried plum and fructooligosaccharides significantly improved whole-body bone mineral density.
- All test compounds increased femoral bone mineral density compared to casein-fed ovariectomized rats.
- The combination of dried plum and fructooligosaccharides had the most pronounced effect on lumbar bone mineral density.
- Urinary deoxypyridinoline excretion was suppressed, indicating reduced bone resorption.
Takeaway
This study found that adding dried plum and a type of sugar called fructooligosaccharides to a soy diet helped rats with bone loss get stronger bones.
Methodology
Seventy-two ovariectomized and sham-operated female rats were divided into six groups and fed different diets for 60 days to assess bone mineral density and biomechanical properties.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Female Sprague-Dawley rats, 3 months old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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