p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer
1999
The Role of p21/WAF1 in Ovarian Cancer
Sample size: 316
publication
Evidence: moderate
Author Information
Author(s): Anttila M A, Kosma V-M, Hongxiu J, Puolakka J, Juhola M, Saarikoski S, Syrjänen K
Primary Institution: Kuopio University Hospital
Hypothesis
The expression of p21/WAF1 is related to p53, cell proliferation, and prognosis in epithelial ovarian cancer.
Conclusion
Low p21/WAF1 expression is associated with poor survival outcomes in patients with epithelial ovarian cancer.
Supporting Evidence
- Low p21/WAF1 expression was significantly associated with high grade of the tumour.
- Low p21/WAF1 expression was associated with advanced FIGO stage.
- Low p21/WAF1 expression was a marker of poor overall survival.
- Patients with p21–/p53+ tumours had poorer overall and recurrence-free survival.
- p21/p53 expression independently predicted tumour recurrence.
Takeaway
This study found that low levels of a protein called p21/WAF1 in ovarian cancer can mean the cancer is more aggressive and harder to treat.
Methodology
Immunohistochemical assessment of p21/WAF1 expression in ovarian cancer samples.
Statistical Information
P-Value
P = 0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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