Genetic Variants and Type 2 Diabetes in South Asians
Author Information
Author(s): Rees Simon D., Hydrie M. Zafar I., O'Hare J. Paul, Kumar Sudhesh, Shera A. Samad, Basit Abdul, Barnett Anthony H., Kelly M. Ann
Primary Institution: College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Hypothesis
The study aims to explore the role of 16 genetic variants associated with fasting glucose and type 2 diabetes in South Asian populations of Punjabi ancestry.
Conclusion
The study suggests that several genetic variants may contribute to fasting glucose variation and type 2 diabetes risk in South Asians.
Supporting Evidence
- 12 of 16 SNPs displayed β-values with the same direction of effect as seen in European studies.
- The SLC30A8 rs11558471 SNP was nominally associated with fasting glucose.
- Alleles of SNPs in ADCY5 and GLIS3 may confer risk of type 2 diabetes in South Asians.
Takeaway
Scientists looked at genes that might affect blood sugar and diabetes in South Asian people and found some that could be important.
Methodology
The study genotyped 16 SNPs in 1678 subjects with type 2 diabetes and 1584 normoglycaemic controls from two Punjabi populations.
Limitations
The study may be underpowered to detect the effects of SNPs on fasting glucose levels due to the modest sample size.
Participant Demographics
Participants were of Punjabi ancestry, predominantly from the District of Mirpur, Pakistan.
Statistical Information
P-Value
p=0.015 for SLC30A8 rs11558471
Confidence Interval
95% CI: 0.013, 0.113
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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