Trends in Sepsis-Associated Cardiovascular Disease Mortality in the US (1999-2022)
Author Information
Author(s): Salman Malik, Cicin Jack, Abdul Jabbar Ali Bin, El-shaer Ahmed, Tauseef Abubakar, Asghar Noureen, Mirza Mohsin, Aboeata Ahmed
Primary Institution: School of Medicine, Creighton University, Omaha, NE, United States
Hypothesis
This study aims to assess the trends of sepsis-associated CVD mortality rates and variations in mortality based on demographics and regions in the US.
Conclusion
Sepsis-associated CVD mortality has increased in the US over the past decade, with worsening demographic disparities since the onset of the COVID-19 pandemic.
Supporting Evidence
- Sepsis-associated CVD mortality decreased from 65.7 in 1999 to 58.8 in 2013, then rose to 74.3 in 2022.
- Mortality rates were highest in men, NH Black adults, and elderly adults (65+ years old).
- The Northeast region was the only area to see a decline in mortality rates during the study period.
- From 1999 to 2013, AAMR for sepsis-associated CVD initially declined, then increased significantly after 2019.
Takeaway
This study looked at how many people died from heart problems related to sepsis over 23 years in the US, finding that more people are dying now, especially among certain groups.
Methodology
Data from the CDC WONDER database was analyzed to identify CVD and sepsis-related deaths from 1999 to 2022, using statistical methods to determine trends.
Potential Biases
Potential inaccuracies in death reporting and the exclusion of certain demographic groups due to changes in data collection.
Limitations
The study relies on death certificate data, which may contain inaccuracies, and cannot determine the causal relationship between sepsis and CVD.
Participant Demographics
Of the deaths, 50.74% were men, 72.12% were Non-Hispanic White adults, 15.70% were Non-Hispanic Black adults, and 81.21% were elderly adults (65+ years old).
Statistical Information
Confidence Interval
95% CI: −2.12% to −0.26%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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