Controlled Release of Mesalamine for Colon Targeting
Author Information
Author(s): Patel J.K., Patel N.V., Shah S.H.
Primary Institution: Nootan Pharmacy College, Visnagar, Gujarat, India
Hypothesis
Can a controlled release matrix formulation effectively deliver mesalamine to the colon?
Conclusion
The study found that a formulation using compritol ATO 888 and pectin can effectively control the release of mesalamine for colon targeting over 24 hours.
Supporting Evidence
- The formulation achieved a 24-hour drug release profile.
- Pectin was effective in targeting the drug to the colon.
- The study utilized scanning electron microscopy to analyze tablet structure.
Takeaway
This study created a special tablet that releases medicine in the colon to help treat diseases like ulcerative colitis, instead of releasing it too early in the stomach.
Methodology
The study used a 32 full factorial design to optimize the formulation and conducted in vitro release tests.
Limitations
The study may not account for all variables affecting drug release in a real-world setting.
Statistical Information
P-Value
0.00080
Statistical Significance
p<0.05
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