Endophytic Fungi Co-Culture: An Alternative Source of Antimicrobial Substances
Author Information
Author(s): Tironi Lucas Silva, Carletto Lucilene Bento, Silva Eliane Oliveira, Schripsema Jan, Luiz Jaine Honorata Hortolan
Primary Institution: Institute of Chemistry, Federal University of Alfenas, Alfenas, Brazil
Hypothesis
The co-culture approach can activate silent biosynthetic gene clusters in endophytic fungi to produce new antimicrobial compounds.
Conclusion
Microbial co-culture is an effective strategy for discovering new natural products with antimicrobial activity and enhancing the production of target substances.
Supporting Evidence
- Co-culturing different fungi can activate hidden pathways to produce new antimicrobial compounds.
- Endophytic fungi are valuable for discovering new natural products due to their ability to produce diverse metabolites.
- Co-culture techniques can enhance the production of known and novel bioactive compounds.
Takeaway
Scientists are growing different fungi together to find new medicines that can fight germs better because some germs are becoming resistant to current drugs.
Methodology
This review discusses the co-culture of endophytic fungi in both liquid and solid media to explore their potential in producing antimicrobial compounds.
Limitations
The review highlights that many endophytic species remain unexplored, and the mechanisms behind the biosynthesis of many substances produced through co-culture are still unknown.
Digital Object Identifier (DOI)
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