Understanding Glycopeptide Resistance in Staphylococcus aureus
Author Information
Author(s): Scherl Alexander, François Patrice, Charbonnier Yvan, Deshusses Jacques M, Koessler Thibaud, Huyghe Antoine, Bento Manuela, Stahl-Zeng Jianru, Fischer Adrien, Masselot Alexandre, Vaezzadeh Alireza, Gallé Francesca, Renzoni Adriana, Vaudaux Pierre, Lew Daniel, Zimmermann-Ivol Catherine G, Binz Pierre-Alain, Sanchez Jean-Charles, Hochstrasser Denis F, Schrenzel Jacques
Primary Institution: Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland
Hypothesis
What molecular targets are involved in glycopeptide resistance in Staphylococcus aureus?
Conclusion
The study identifies numerous proteins and genes involved in glycopeptide resistance, providing potential targets for diagnostics and treatment.
Supporting Evidence
- The study identified 94 differentially expressed genes and 178 proteins related to glycopeptide resistance.
- Massively parallel methods allowed the identification of one third of the complete proteome.
- The findings suggest that glycopeptide resistance is a stable phenomenon acquired by Staphylococcus aureus.
Takeaway
Scientists studied bacteria that resist antibiotics to find out how they do it, which could help in treating infections better.
Methodology
The study used whole-genome microarray-based transcription and quantitative proteomic profiling on isogenic strains of Staphylococcus aureus.
Limitations
The difficulty in obtaining isogenic strains with various susceptibility phenotypes limits the study's findings.
Digital Object Identifier (DOI)
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