Nitric Oxide Administration Using an Oxygen Hood: A Pilot Trial
Author Information
Author(s): Ambalavanan Namasivayam, El-Ferzli George T., Roane Claire Johnson, Robert Carlo Waldemar A.
Primary Institution: University of Alabama at Birmingham
Hypothesis
The study aimed to determine the feasibility of inhaled nitric oxide (iNO) administered by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients.
Conclusion
Administration of iNO by oxygen hood is feasible, but larger trials are needed to measure efficacy.
Supporting Evidence
- Two of the four infants given iNO had an increase in PaO2 of >100 torr.
- Oxygenation was unchanged in the controls.
- Methemoglobinemia and other adverse effects were not noted in any infant.
- Environmental levels of NO and NO2 were minimal at >0.3 m from the hood.
Takeaway
This study tested a new way to give a gas called nitric oxide to babies who have trouble getting enough oxygen, and it worked for some of them.
Methodology
Masked randomized controlled pilot trial with infants randomized to receive either iNO or oxygen for one hour.
Limitations
The study had a small sample size and was terminated due to slow enrollment.
Participant Demographics
Eight term or near-term infants, with a mix of diagnoses including persistent pulmonary hypertension and sepsis.
Digital Object Identifier (DOI)
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