Differential regulation of MAP kinase cascade in human colorectal tumorigenesis
1999
MAPK Pathway in Colorectal Cancer
Sample size: 21
publication
Evidence: moderate
Author Information
Author(s): Park K-S, Kim N-G, Kim J J, Kim H, Ahn Y H, Choi K-Y
Primary Institution: Yonsei University College of Medicine
Hypothesis
The study investigates the role of the MAPK pathway in colorectal tumorigenesis.
Conclusion
The study found that MAPK activities are down-regulated in most colorectal tumors, suggesting a role in the loss of normal growth control.
Supporting Evidence
- 71% of colorectal tumors showed two- to tenfold lower MAPK activities compared to paired normals.
- MAPK activities were down-regulated in both adenomas and carcinomas.
- MAPK activities in carcinomas were higher than in paired adenomas.
Takeaway
The study looked at how a specific pathway in cells, called MAPK, behaves in colorectal cancer, finding that it often doesn't work as it should.
Methodology
The study examined MAPK activities in 21 colorectal tumor specimens and compared them with paired normal tissues.
Statistical Information
P-Value
0.006
Statistical Significance
p=0.006
Digital Object Identifier (DOI)
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