Fucoidan from Marine Brown Algae Inhibits Lipid Accumulation
2011
Fucoidan from Marine Brown Algae Reduces Fat Accumulation
publication
Evidence: moderate
Author Information
Author(s): Park Min-Kyoung, Uhee Roh, Changhyun
Primary Institution: Korea Atomic Energy Research Institute (KAERI)
Hypothesis
Does fucoidan from marine brown algae inhibit lipid accumulation in 3T3-L1 adipocytes via stimulating lipolysis?
Conclusion
Fucoidan reduces lipid accumulation in adipocytes by stimulating lipolysis.
Supporting Evidence
- Fucoidan treatment reduced lipid accumulation by 52.2% at 200 μg/mL concentration.
- The protein levels of hormone sensitive lipase (HSL) and phosphorylated-HSL increased significantly with fucoidan treatment.
- Insulin-induced glucose uptake was decreased by 51% in fucoidan-treated cells.
Takeaway
Fucoidan, a substance from brown seaweed, helps stop fat from building up in fat cells, which could help with obesity.
Methodology
The study used Oil Red O staining to measure lipid accumulation in 3T3-L1 adipocytes and western blotting to assess protein levels of hormone sensitive lipase.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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