Managing Blood Flow and Recovery After Cancer Surgery
Author Information
Author(s): Solanki Sohan Lal, Agarwal Vandana, Ambulkar Reshma P., Joshi Malini P., Chawathey Shreyas, Rudrappa Shivacharan Patel, Bhandare Manish, Saklani Avanish P.
Primary Institution: Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
Hypothesis
Effective hemodynamic management during and after the procedure is associated with improved outcomes, including a reduction in complications, shorter hospital stays, and lower postoperative morbidity and mortality.
Conclusion
A higher PCI score was significantly associated with increased duration of surgery, fluid requirements, the need for invasive hemodynamic monitoring, postoperative complications, and longer ICU stays.
Supporting Evidence
- Patients with PCI > 20 had significantly longer surgeries compared to those with lower PCI scores.
- Fluid requirements were higher in patients with greater tumor burden.
- Patients with higher PCI scores experienced longer ICU stays.
Takeaway
This study shows that patients with more cancer in their abdomen need more fluids and longer surgeries, which can lead to more complications.
Methodology
This prospective observational study included 203 patients undergoing CRS-HIPEC, with data collected on fluid management, hemodynamic parameters, and postoperative outcomes.
Limitations
The study is a single-center study, limiting generalizability, and lacked a predefined sample size.
Participant Demographics
{"age":{"median":49,"interquartile_range":[37,58]},"sex_distribution":{"male":89,"female":114},"diagnosis_distribution":{"colorectal_cancer":69,"stomach_cancer":35,"ovarian_cancer":34,"pseudomyxoma_peritonei":30,"carcinoma_of_the_appendix":24,"mesothelioma":8,"others":3}}
Statistical Information
P-Value
p ≤ 0.01
Statistical Significance
p ≤ 0.01
Digital Object Identifier (DOI)
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