Epithelial–Mesenchymal Transition in Non-Small Cell Lung Cancer Management: Opportunities and Challenges
Author Information
Author(s): Ye Yunyao, Yu Shanxun, Guo Ting, Zhang Sihui, Shen Xiaozhou, Han Gaohua
Primary Institution: Taizhou People’s Hospital Affiliated to Nanjing Medical University
Hypothesis
This review aims to elucidate the effect of EMT on metastasis and the tumor immune microenvironment.
Conclusion
Targeting EMT may improve treatment efficacy and inhibit tumor growth and progression in non-small cell lung cancer.
Supporting Evidence
- EMT is a critical step in cancer metastasis.
- Targeting EMT may improve treatment outcomes for NSCLC.
- EMT contributes to immunosuppression in the tumor microenvironment.
- Different EMT states can influence treatment responses.
- CTCs exhibit features of EMT and are linked to metastasis potential.
- Organ-specific metastasis is influenced by the tumor microenvironment.
- EMT can induce drug resistance in cancer cells.
- Understanding EMT can lead to better therapeutic strategies.
Takeaway
This study talks about how cancer cells change to become more aggressive and how this affects treatment. By stopping these changes, we might help patients get better.
Methodology
This is a review summarizing molecular mechanisms involved in EMT affecting tumor progression and immunotherapy outcomes.
Limitations
The review does not provide original experimental data and relies on existing literature.
Digital Object Identifier (DOI)
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