A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women
2006

Comparing Two Prenatal Supplements for Pregnant Women

Sample size: 135 publication Evidence: moderate

Author Information

Author(s): Eric Ahn, Nicholas Pairaudeau, Nicholas Pairaudeau Jr., Yves Cerat, Bernard Couturier, Andre Fortier, Eric Paradis, Gideon Koren

Primary Institution: The University of Toronto

Hypothesis

Is a new micronutrient supplement with lower iron content more tolerable than a high iron supplement for pregnant women?

Conclusion

PregVit®, a supplement with lower iron content, has significantly decreased constipation rates compared to Materna and has similar compliance rates.

Supporting Evidence

  • PregVit® was associated with a 30% reduction in constipation rate compared to Materna®.
  • Both products demonstrated similar compliance rates.
  • Compliance with Materna® was negatively associated with the severity of nausea and vomiting of pregnancy.

Takeaway

PregVit® is easier for pregnant women to take because it causes less constipation than another supplement with more iron.

Methodology

Randomized, crossover open labeled study.

Potential Biases

Participants who dropped out did not differ from those who completed the study.

Limitations

High dropout rate and the study's design may improve compliance artificially.

Participant Demographics

Pregnant women aged 18 to 45.

Statistical Information

P-Value

0.03

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1471-2393-6-10

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