Nitric Oxide Levels in Tuberculosis Patients with HIV
Author Information
Author(s): Idh Jonna, Westman Anna, Elias Daniel, Moges Feleke, Getachew Assefa, Gelaw Aschalew, Sundqvist Tommy, Forslund Tony, Alemu Addis, Ayele Belete, Diro Ermias, Melese Endalkachew, Wondmikun Yared, Britton Sven, Stendahl Olle, Schön Thomas
Primary Institution: Linköping University
Hypothesis
The study aims to investigate levels of fractional exhaled nitric oxide (FeNO) in relation to clinical symptoms and urinary nitric oxide metabolites in tuberculosis patients with and without HIV co-infection.
Conclusion
Both HIV negative and HIV co-infected TB patients showed low levels of exhaled nitric oxide compared to blood donors and household contacts.
Supporting Evidence
- HIV-/TB patients had a higher proportion of increased FeNO levels compared to HIV+/TB patients.
- HIV+/TB patients had significantly higher urinary NO levels than HIV-/TB patients.
- Both TB patient groups had lower FeNO levels compared to blood donors and household contacts.
Takeaway
The study found that people with tuberculosis and HIV have lower levels of a gas called nitric oxide in their breath compared to healthy people.
Methodology
A cross-sectional study measuring FeNO and urinary NO metabolites in TB patients and their contacts.
Potential Biases
Potential bias due to exclusion criteria and the specific population studied.
Limitations
The study was limited to a specific population in Ethiopia and may not be generalizable to other settings.
Participant Demographics
The study included 95 TB patients (36 HIV positive, 59 HIV negative), with a mix of male and female participants aged 15-60.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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