Genetic Factors and Smoking in Colorectal Cancer Risk
Author Information
Author(s): Kasahara Mayumi, Osawa Kayo, Yoshida Kana, Miyaishi Aiko, Osawa Yasunori, Inoue Natsuko, Tsutou Akimitsu, Tabuchi Yoshiki, Tanaka Kenichi, Yamamoto Masahiro, Shimada Etsuji, Takahashi Juro
Primary Institution: Kobe University Graduate School of Medicine
Hypothesis
The study aims to measure the interactions between polymorphisms of DNA repair genes and tobacco smoking in colorectal cancer.
Conclusion
The MUTYH Gln324His and APEX1 Asp148Glu polymorphisms are associated with an increased risk of colorectal cancer, particularly colon cancer, influenced by smoking status.
Supporting Evidence
- The MUTYH Gln324His genotype is significantly associated with colorectal cancer risk.
- The APEX1 Asp148Glu genotype shows increased risk of colorectal cancer in smokers.
- Non-smokers with the MUTYH Gln324His genotype have a higher risk of colorectal cancer.
- Statistical analysis showed significant odds ratios for both genetic polymorphisms.
- Genetic polymorphisms may interact with environmental factors like smoking.
Takeaway
Some genes can make people more likely to get colon cancer, especially if they smoke. This study looked at how these genes and smoking work together.
Methodology
A case-control study with 68 colorectal cancer patients and 121 non-cancer controls, examining genetic polymorphisms using PCR-RFLP.
Potential Biases
Potential bias due to the small number of participants and selection from a hospital setting.
Limitations
The study is limited by its small sample size and hospital-based design.
Participant Demographics
68 colorectal cancer patients (40 colon cancer, 23 rectal cancer) and 121 controls, with a mix of genders and ages.
Statistical Information
P-Value
0.005 for MUTYH Gln324His; 0.002 for APEX1 Asp148Glu
Confidence Interval
95%CI 1.44–7.60 for MUTYH; 95%CI 1.45–4.99 for APEX1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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